Quantifying haemoglobin A2 And F is important for determining the severity of illnesses and identifying certain blood disorders.
Haemoglobin is an iron-rich protein found in blood that plays a vital role in body function. It is present in the body in various forms, with A2 and F being the less common forms. However, like the other types, they play vital roles in maintaining a healthy body.
Understanding Haemoglobin A2 (HbA2)
HbA2 is a relatively minor constituent, accounting for about two to three per cent of all haemoglobin in a healthy person. This form of haemoglobin is often quantified to diagnose hemoglobinopathies like beta-thalassemia.
Haemoglobin A2 levels tend to rise in beta-thalassemia carriers, functioning as a diagnostic marker for the condition. HbA2 levels are often measured using specialist laboratory methods, such as high-performance liquid chromatography (HPLC).
About Haemoglobin F (HbF)
Haemoglobin F, also known as foetal haemoglobin, is found mostly in foetuses and infants, accounting for about 80 to 90 per cent of all haemoglobin present at birth. HbF synthesis declines as the individual grows, and haemoglobin A becomes the main form of haemoglobin.
HbF is clinically significant because it persists in some individuals, a disease referred to as hereditary persistence of foetal haemoglobin (HPFH). In such circumstances, HbF levels stay elevated for the rest of a person’s life.
By compensating for the deficiency of haemoglobin A, this condition can alleviate the symptoms of some haemoglobin diseases, such as sickle cell anaemia and beta-thalassemia. Scientists are investigating the genetic basis of HPFH to develop possible therapeutics for haemoglobin-related disorders.
Final Thoughts
Understanding HbA2 and HbF levels is crucial for the diagnosis and treatment of certain blood disorders. At Trinity Biotech, we are committed to ensuring that researchers have access to the tools they need to quantify haemoglobin levels.
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